Lineas de Investigación
1. Genómica Funcional y Proteómica del Cáncer
2. Bases celulares y moleculares de la síntesis de glutamato en cerebro
3. Modelos animales transgénicos con déficits en el metabolismo de aminoácidos
4. Expresión heteróloga de proteínas humanas recombinantes con valor terapéutico y biotecnológico
Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Tecnico Laboratorio
- Otro
Proyectos de Investigación
Terapia metabólica del cáncer: supresión tumoral inducida por desregulación de glutaminasa (RTI2018-096866-B-I00).
Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia, Innovación y Universidades
2019
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation
García-Ponce ÁL, Martínez-Poveda B, Blanco-López Á, Quesada AR, Suárez F, et al. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2021 Mar;49(2):236-241
Antioxidant responses related to temozolomide resistance in glioblastoma
Campos-Sandoval JA, Gómez-García MC, Santos-Jiménez JL, Matés JM, Alonso FJ, et al. Neurochemistry international 2021 Oct;149():105136
Tumor Metabolome: Therapeutic Opportunities Targeting Cancer Metabolic Reprogramming
Márquez J, Matés JM Cancers 2021 Jan 16;13(2):
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells
de Los Santos-Jiménez J, Campos-Sandoval JA, Márquez-Torres C, Urbano-Polo N, Brøndegaard D, et al. Journal of biomedical science 2021 Feb 20;28(1):14
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
Ojeda-Pérez B, Campos-Sandoval JA, García-Bonilla M, Cárdenas-García C, Páez-González P, et al. Fluids and barriers of the CNS 2021 Jul 2;18(1):30
Glutaminases regulate glutathione and oxidative stress in cancer
Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Márquez J Archives of toxicology 2020 Aug;94(8):2603-2623
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes
Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Segura JA, Alonso FJ, et al. Current medicinal chemistry 2020;27(32):5317-5339
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, et al. Scientific reports 2020 Feb 10;10(1):2259
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Matés JM, Di Paola FJ, Campos-Sandoval JA, Mazurek S, Márquez J Seminars in cell & developmental biology 2020 Feb;98():34-43
Dysregulation of glutaminase and glutamine synthetase in cancer
Matés JM, Campos-Sandoval JA, Santos-Jiménez JL, Márquez J Cancer letters 2019 Dec 28;467():29-39
Lysophosphatidic Acid and Glutamatergic Transmission
Roza C, Campos-Sandoval JA, Gómez-García MC, Peñalver A, Márquez J Frontiers in molecular neuroscience 2019;12():138
The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression
Ramirez-Peña E, Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, et al. Cancers 2019 Oct 22;11(10):
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway
Majewska E, Márquez J, Albrecht J, Szeliga M Cancers 2019 Jan 19;11(1):
A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.
García-Bonilla M, García-Martín ML, Muñoz-Hernández MC, Domínguez-Pinos D, Martínez-León MI, et al. Journal of neuropathology and experimental neurology 2018 Dec 1;77(12):1122-1136
Glutaminase isoenzymes in the metabolic therapy of cancer
Matés JM, Campos-Sandoval JA, Márquez J Biochimica et biophysica acta. Reviews on cancer 2018 Dec;1870(2):158-164
Glutamate and Brain Glutaminases in Drug Addiction
Márquez J, Campos-Sandoval JA, Peñalver A, Matés JM, Segura JA, et al. Neurochemical research 2017 Mar;42(3):846-857
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver A, Campos-Sandoval JA, Blanco E, Cardona C, Castilla L, et al. Frontiers in molecular neuroscience 2017;10():278
Glutamine Addiction In Gliomas
Márquez J, Alonso FJ, Matés JM, Segura JA, Martín-Rufián M, et al. Neurochemical research 2017 Jun;42(6):1735-1746
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, et al. Cancer cell 2017 Jul 10;32(1):71-87.e7
TRANSCRIPTION FACTOR GATA3 EXPRESSION IS INDUCED BY GLS2 OVEREXPRESSION IN A GLIOBLASTOMA CELL LINE BUT IS GLS2-INDEPENDENT IN PATIENT-DERIVED GLIOBLASTOMA
Majewska E, Rola R, Barczewska M, Marquez J, Albrecht J, et al. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Apr;68(2):209-214
Synthesis and Covalent Grafting of Tripod-Shaped Oligo(p-phenylene)s End-Capped with Azide Groups
Sanchez-Molina, M; Lopez-Romero, JM; Hierrezuelo-Leon, J; Martin-Rufian, M; Diaz, A; Valpuesta, M; Contreras-Caceres, R ASIAN JOURNAL OF ORGANIC CHEMISTRY 2016
Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes
Cardona C, Sánchez-Mejías E, Dávila JC, Martín-Rufián M, Campos-Sandoval JA, et al. Glia 2015 Mar;63(3):365-82
Glutaminases in brain: Multiple isoforms for many purposes
Campos-Sandoval JA, Martín-Rufián M, Cardona C, Lobo C, Peñalver A, et al. Neurochemistry international 2015 Sep;88():1-5
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, et al. Nature medicine 2015 Oct;21(10):1182-9
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
Arrabal S, Lucena MA, Canduela MJ, Ramos-Uriarte A, Rivera P, et al. PloS one 2015;10(12):e0145244
Enlaces
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