Modelos Animales en Investigaciones Cardiovasculares
Grupo universitario con experiencia en investigaciones sobre el sistema cardiovascular en Vertebrados, utilizando modelos animales de enfermedad de relevancia biomédica
Lineas de Investigación
01. Etiología y fisiopatología de la enfermedad de la válvula aórtica bicúspide.
02. Etiología de las anomalías congénitas de las arterias coronarias
03. Modelos animales de aterosclerosis
04. Crecimiento vascular: angiogénesis y arteriogénesis
05. Desarrollo embrionario del sistema cardiovascular.
06. Anatomía comparada y evolución del sistema cardiovascular.
Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Tecnico Laboratorio
- Otro
Proyectos de Investigación
Mioarquitectura y vascularización del corazón primitivo de los Gnatostomados: su implicación en los cambios morfológico-adaptativos del sistema circulatorio de los Vertebrados
Ministerio de Economía y Competitividad.
.
2017
Desarrollo embrionario del origen anatómico de las arterias coronarias en vertebrados gnatostomados. Implicaciones evolutivas
Ministerio de Economía y Competitividad
.
2017
Identificación de una variante alélica de Smad2 asociada a la enfermedad de la válvula aórtica bicúspide en una población de pacientes.
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud.
.
2020
Aortopatía Bicúspide. 2021-2023
Consejería de transformación económica, industria, conocimiento y universidades, Junta de Andalucía
.
2021
Area1_002:Identificación de una variante alélica de Smad2 asociada a la enfermedad de la válvula aórtica bicúspide en una población de pacientes
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
.
2020
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, et al. The Annals of thoracic surgery 2021 Sep;112(3):e203-e235
International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, et al. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2021 Sep 11;60(3):448-476
International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, et al. The Journal of thoracic and cardiovascular surgery 2021 Sep;162(3):e383-e414
Summary: International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, et al. The Annals of thoracic surgery 2021 Sep;112(3):1005-1022
Summary: international consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, et al. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2021 Sep 11;60(3):481-496
Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional, and research purposes
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, et al. The Journal of thoracic and cardiovascular surgery 2021 Sep;162(3):781-797
Bicuspid Aortic Valve in 2 Model Species and Review of the Literature
Fernández B, Soto-Navarrete MT, López-García A, López-Unzu MÁ, Durán AC, et al. Veterinary pathology 2020 Mar;57(2):321-331
Development of the ventricular myocardial trabeculae in Scyliorhinus canicula (Chondrichthyes): evolutionary implications
López-Unzu MA, Durán AC, Rodríguez C, Soto-Navarrete MT, Sans-Coma V, et al. Scientific reports 2020 Sep 2;10(1):14434
Embryonic development of bicuspid aortic valves
Soto-Navarrete MT, López-Unzu MÁ, Durán AC, Fernández B Progress in cardiovascular diseases 2020 Jul – Aug;63(4):407-418
Myosin heavy chain isoforms in the myocardium of the atrioventricular junction ofScyliorhinus canicula(Chondrichthyes, Carcharhiniformes)
López-Unzu MA, Soto-Navarrete MT, Sans-Coma V, Fernández B, Durán AC Journal of fish biology 2020 Sep;97(3):734-739
Differential expression of myosin heavy chain isoforms in cardiac segments of gnathostome vertebratesand its evolutionary implications
López-Unzu MA, Durán AC, Soto-Navarrete MT, Sans-Coma V, Fernández B Frontiers in zoology 2019;16():18
Pigmentation of the aortic and pulmonary valves in C57BL/6J x Balb/cByJ hybrid mice of different coat colours
Sánchez-Piña J, Lorenzale M, Fernández MC, Durán AC, Sans-Coma V, et al. Anatomia, histologia, embryologia 2019 Sep;48(5):429-436
The Bicuspid Condition of the Aortic Valve Does Not Alter the Incidence of Accessory Coronary Artery Ostia in Syrian Hamsters (Mesocricetus auratus)
Fernández MC, Soto-Navarrete MT, Durán AC, Sans-Coma V, Fernández B Journal of comparative pathology 2019 Jan;166():9-16
The valves of the cardiac outflow tract of the starry ray, Raja asterias (Chondrichthyes; Rajiformes): Anatomical, histological and evolutionary aspects
Lorenzale M, Fernández B, Durán AC, López-Unzu MA, Sans-Coma V Anatomia, histologia, embryologia 2019 Jan;48(1):40-45
The anatomical components of the cardiac outflow tract of chondrichthyans and actinopterygians
Lorenzale M, López-Unzu MA, Rodríguez C, Fernández B, Durán AC, et al. Biological reviews of the Cambridge Philosophical Society 2018 Aug;93(3):1604-1619
The arrangement of the coronary artery trunks is subject to inheritance factors: A study in Syrian hamsters
Soto-Navarrete MT, Arqué JM, Durán AC, Fernández MC, López-Unzu MA, et al. Anatomia, histologia, embryologia 2018 Apr;47(2):140-144
Anatomical, histochemical and immunohistochemical characterisation of the cardiac outflow tract of the silver arowana, Osteoglossum bicirrhosum (Teleostei: Osteoglossiformes)
Lorenzale M, López-Unzu MA, Fernández MC, Durán AC, Fernández B, et al. Zoology (Jena, Germany) 2017 Feb;120():15-23
Cardiac, mandibular and thymic phenotypical association indicates that cranial neural crest underlies bicuspid aortic valve formation in hamsters
Martínez-Vargas J, Ventura J, Machuca Á, Muñoz-Muñoz F, Fernández MC, et al. PloS one 2017;12(9):e0183556
Dicephalous v. diprosopus sharks: record of a two-headed embryo of Galeus atlanticus and review of the literature
Sans-Coma V, Rodríguez C, López-Unzu MA, Lorenzale M, Fernández B, et al. Journal of fish biology 2017 Jan;90(1):283-293
Fibrillin 2 is upregulated in the ascending aorta of patients with bicuspid aortic valve
Rueda-Martínez C, Lamas O, Mataró MJ, Robledo-Carmona J, Sánchez-Espín G, et al. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2017 Jan;51(1):104-111
Increased blood levels of transforming growth factor beta in patients with aortic dilatation
Rueda-Martínez C, Lamas O, Carrasco-Chinchilla F, Robledo-Carmona J, Porras C, et al. Interactive cardiovascular and thoracic surgery 2017 Oct 1;25(4):571-574
The bulbus arteriosus of the holocephalan heart: gross anatomy, histomorphology, pigmentation, and evolutionary significance
Rodríguez C, Lorenzale M, López-Unzu MA, Fernández B, Salmerón F, et al. Zoology (Jena, Germany) 2017 Aug;123():37-45
Identification of Reference Genes for Quantitative Real Time PCR Assays in Aortic Tissue of Syrian Hamsters with Bicuspid Aortic Valve
Rueda-Martínez C, Fernández MC, Soto-Navarrete MT, Jiménez-Navarro M, Durán AC, et al. PloS one 2016;11(10):e0164070
The relative length of the cardiac bulbus arteriosus reflects phylogenetic relationships among elasmobranchs
Rodriguez, C; Fernandez, B; Olivero, J; Salmeron, F; Torres-Prioris, A; Sans-Coma, V; Duran, AC ZOOLOGISCHER ANZEIGER 2016
Unusual anatomical origins of the coronary arteries in C57BL/6 mice. Are they strain-specific?
López-García A, Soto-Navarrete MT, Fernández MC, Moncayo-Arlandi J, Durán AC, et al. Journal of anatomy 2016 Nov;229(5):703-709
Heart Pigmentation in the Gray Bichir, Polypterus senegalus (Actinopterygii: Polypteriformes)
Reyes-Moya I, Torres-Prioris A, Sans-Coma V, Fernández B, Durán AC Anatomia, histologia, embryologia 2015 Dec;44(6):475-80
Quadricuspid aortic valves in Syrian hamsters and their formation according to current knowledge on valvulogenesis
López-García A, Carmen Fernández M, Durán AC, Sans-Coma V, Fernández B The Japanese journal of veterinary research 2015 Feb;63(1):37-43
Structure and vascularization of the ventricular myocardium in Holocephali: their evolutionary significance
Durán AC, López-Unzu MA, Rodríguez C, Fernández B, Lorenzale M, et al. Journal of anatomy 2015 Jun;226(6):501-10
Enlaces
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Parque Tecnol?gico de Andaluc?a (PTA) Campanillas,
M?laga 29590
(+34) 951 440 260
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