Lineas de Investigación
Estudio de las bases biológicas del comportamiento y la fisiopatología de enfermedades degenerativas de gran prevalencia. Estas incluyen los trastornos adictivos (abuso de drogas), los trastornos de la alimentación (obesidad, diabetes, dislipemia), la enfermedad de Alzheimer, así como los síndromes de ansiedad y depresión, a lo largo del desarrollo y en modelos de enfermedad (comorbilidad psiquiátrica)..
01. Esteatohepatitis alcohólica y no alcohólica.
02. Programación metabólica durante el desarrollo y crecimiento (obesidad, diabetes)
03. Desarrollo de nuevas entidades químicas terapéuticas o nuevas indicaciones de fármacos existentes.
04 Evaluación farmacológica de alimentos de uso médico especial (ADUME).
Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Tecnico Laboratorio
- Otro
Proyectos de Investigación
Área 3.Neurociencias, Cronicidad, Envejecimiento y Salud en poblaciones vulnerables.PLAN PROPIO_AREA 3
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludMOV20-002 Análisis de perfiles inflamatorios en pacientes usuarios con trastornos psiquiátricos comorbidos: Depresión, Deterioro cognitivo y uso de alcohol. Candidato: María Flores López. Jefe de Grupo: Antonia María Serrano Criado
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludMOV20-001 Análisis del mecanismo de autofagia en modelos animales de Alzheimer de última generación. Candidato: Dina Medina Vera, Jefe de Grupo: Fernando Rodríguez de Fonseca
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludCD20/00192 Contratos Sara Borrell 2020 Sara Peñasco Iglesias. Jefe de Grupo: Fernando Rodriguez de Fonseca
Instituto de Salud Carlos IIIPI20/01399 Papel de la señalización lipídica mediada por monoacilgliceroles y ácido lisofosfatídico en la Asociación entre trastornos por uso de alcohol y Depresión: Identificación de Biomarcadores
Instituto de Salud Carlos IIIP18-TP-5194 VALIDACIÓN PRECLINICA DE LOS INOSITOLES DE LA ALGARROBA SOBRE TRASTORNOS ASOCIADOS A LA RESISTENCIA INSULINICA
Consejería de Transformación Económica, Industria, Conocimiento y UniversidadesRTC2019-007329-1 Obtención de principios activos antioxidantes a partir de la vaina del algarrobo y validación de su potencial terapéutico. Fernando Rodriguez de Fonseca.
Agencia Estatal de InvestigaciónCOV20/00157 Afectación neurológica en la enfermedad Covid-19 clinicamente relevante. ¿Existe la enfermedad Neuro-Covid-19?
Instituto de Salud Carlos IIIEuronutra S.L. RRHH
EuronutraIFI18/00042 Contrato i-PFIS 2018 Antonio Jesús López Gambero.
Instituto de Salud Carlos III (ISCIII)RTC2019-007329-1: Obtención de principios activos antioxidantes a partir de la vaina del algarrobo y validación de su potencial terapéutico | El objetivo tecnológico principal de esta línea de I+D se basa en la extracción y obtención de principios activos naturales de una fracción del fruto del algarrobo para el tratamiento de enfermedades metabólicas crónicas como el NASH, del neurodesarrollo (síndrome de Down, síndrome de X-Frágil) y psiquiátricas infantiles (trastorno por déficit de atención e hiperactividad, TDH), sin tratamiento específico que cursan con deterioro metabólico y/o cognitivo abordando para ello el diseño e ingeniería de una tecnología complementaria que permita desarrollar y completar el reto que supone el presente proyecto.
Agencia Estatal de Investigación. Ministerio de Ciencia e InnovaciónPapel de la señalización lipídica mediada por monoacilgliceroles y ácido lisofosfatídico en la asociación entre trastornos por uso de alcohol y depresión: iIdentificación de biomarcadores.
ISCIIIMV19/00060 Papel de las aciletanolamidas y los acilgliceroles en el consumo abusivo de alcohol durante la adolescencia y la vulnerabilidad a desarrollar trastornos por uso de alcohol.
ISCIIIPEIBA-2019-040 BIOMARCADORES CIRCULANTES DE COMORBILIODAD NEUROLÓGICA EN EL TRASTORNO POR CONSUMO TEMPRANO DE ALCOHOL Y/O DROGAS ILEGALES: HERRAMIENTA PREDICTIVA DE DETERIORO COGNITIVO Y DEMENCIAS EN POBLACIONES VULNERABLES.
Ministerio de Sanidad, Consumo y Bienestar SocialPI19/00343 Estudio de nuevos factores del sistema GH/IGF: análisis de mecanismos moleculares que regulan crecimiento y metabolismo mediane PAPP-A2 y desarrollo de nuevas terapias.
ISCIIICPII19/00031 Contratos Miguel Servet Tipo II 2019
ISCIIIEIN2019-103364 – INNOVATIVE DUAL LIGANDS FOR THE TREATMENT OF ALCOHOL USE DISORDERS AND ITS COMPLICATIONS
Agencia Estatal de InvestigaciónDTS19/00125 Evaluación preclínica de ligandos duales para el tratamiento de los trastornos por uso de alcohol
ISCIIIPI19/01577 Alcohol, depresión y deterioro cognitivo: Papel de las aciletanolamidas no cannabinoides. IP Fernando Rodriguez de Fonseca
ISCIIIPI19/01577 Alcohol, depresión y deterioro cognitivo: Papel de las aciletanolamidas no cannabinoides. IP Fernando Rodriguez de Fonseca
ISCIIIEstancia Universidad de Roma-Sapienza
Sapienza University of RomaERASMUS+: Intestinal Neoplasia
ISCIIIFATZHEIMER: High Fat Diet, Microbiota and Neuroinflammation in the Progression of Alzheimer Disease
European Comission (H2020)Consumo de alcohol durante la adolescencia: Papel del sistema endocannabinoide en el desarrollo de adicción al alcohol y trastornos afectivos y de ansiedad comórbidos.
Ministerio de Sanidad, Servicios Sociales e IgualdadPapel del ácido lisofosfatídico en el alcoholismo y la cormobilidad psiquiátrica: implicaciones terapéuticas y evaluación de biomarcadores
CONSEJERÍA DE SALUDEarly life stress and excessive alcohol consumption in adolescents: Role of the endocannabinoid system in the vulnerability to alcoholism
INSTITUTO DE SALUD CARLOS IIIRed de Trastornos Adictivos (Red RTA)
INSTITUTO DE SALUD CARLOS IIIImplicación del Sistema endocannabinoide en la vulnerabilidad al alcoholismo en adultos tras el consumo abusivo durante la adolescencia
CONSEJERÍA DE SALUDCD17/00125 Sara Borrell 2017 Victor Echeverry Alzaty.Jefe de Grupo Fernando Rodriguez de Fonseca
INSTITUTO DE SALUD CARLOS IIIFI17/00027 Contrato PFIS 2017 Laura Sanchez Marin.Jefe de Grupo: Fernando Rodriguez de Fonseca
INSTITUTO DE SALUD CARLOS IIIPI-0139-2018 ESTUDIO DE LA ACTIVACIÓN DEL RECEPTOR PARA GLP1 COMO BASE DEL DESARROLLO DE TERAPIAS COMBINADAS PARA EL TRATAMIENTO DE LA ESTEATOHEPATITIS NO ALCOHÓLICA
CONSEJERÍA DE SALUDCPII17/00024 Miiguel Servet Tipo II 2017 Juan Suarez Pérez
INSTITUTO DE SALUD CARLOS IIIPI16/01374 Obesidad infantil grave de comienzo precoz al diagnóstico y tras pérdida ponderal: Fundamentos metabólicos, hormonales, genéticos, genómicos, metabolómicos y de microbiota
INSTITUTO DE SALUD CARLOS IIIRC-0003-2018 Acción C Nicolás Monarde F.Rodríguez de Fonseca
SERVICIO ANDALUZ DE SALUDPRX18/00608 Estancias de movilidad de profesores e investigadores seniores en centros extranjeros de enseñanza superior e investigación, incluido el Programa Salvador de Madariaga 2018. Investigador: Fernando Antonio Rodríguez de Fonseca
MINISTERIO DE EDUCACIÓN Y FORMACIÓN PROFESIONALRD16/0017/0001 Red de Trastornos Adictivos
INSTITUTO DE SALUD CARLOS IIIPND2018/044 BIOMARCADORES CIRCULANTES DE COMORBILIDAD PSIQUIÁTRICA EN EL TRASTORNO POR USO DE DROGAS: COMPARACIÓN CON BIOMARCADORES DE TRASTORNO DEPRESIVO Y TRASTORNO PSICÓTICO
MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIALRTC-2016-4983-1 Diseño, ingeniería y ensamblaje de línea piloto de nuevos extractos naturales solvent free y validacion in vivo de compuestos bioactivos
MINISTERIO DE ECONOMIA Y EMPRESAPI16/01698 Lípidos transmisores derivados del ácido oleico: Estudio traslacional de su papel en los trastornos por uso de alcohol
INSTITUTO DE SALUD CARLOS IIIDTS16/00115 Desarrollo de nuevos conjugados de ácidos grasos para el tratamiento de las esteatohepatitis
INSTITUTO DE SALUD CARLOS IIIPSI2015-73156-JIN Incremento de la neurogénesis hipocampal adulta como estrategia terapéutica para las alteraciones conductuales inducidas por cocaína (COCANEUROGNSIS)
MINISTERIO DE ECONOMIA Y EMPRESAMS14/00173 Contrato Miguel Servet Tipo I Antonia Mª Serrano Criado
INSTITUTO DE SALUD CARLOS III2017i043 Consumo de alcohol durante la adolescencia: papel del sistema endocannabinoide en el desarrollo de adicción al alcohol y trastornos afectivos y de ansiedad comórbidos
MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIALPI17/02026 Estudio Traslacional del Papel del Sistema Endocannabinoide en la Amígdala Ampliada en la Ansiedad Asociada a la Dependencia Alcohólica
INSTITUTO DE SALUD CARLOS IIIPublicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”.
Decara, Juan M; Vazquez-Villa, Henar; Brea, Jose; Alonso, Monica; Srivastava, Raj Kamal; Orio, Laura; Alen, Francisco; Suarez, Juan; Baixeras, Elena; Garcia-Carceles, Javier; Escobar-Pena, Andrea; Lutz, Beat; Rodriguez, Ramon; Codesido, Eva; Garcia-Ladona, F Javier; Bennett, Teresa A; Ballesteros, Juan A; Cruces, Jacobo; Loza, Maria I; Benhamu, Bellinda; Rodriguez de Fonseca, Fernando; Lopez-Rodriguez, Maria L…Less Journal of medicinal chemistry 2022
A combination of circulating chemokines as biomarkers of obesity-induced insulin resistance at puberty
Rivera, P; Martos-Moreno, GA; Barrios, V; Suarez, J; Pavon, FJ; Chowen, JA; de Fonseca, FR; Argente, J PEDIATRIC OBESITY 2021
A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse
López-Gambero AJ, Rosell-Valle C, Medina-Vera D, Navarro JA, Vargas A, et al. International journal of molecular sciences 2021 May 20;22(10):
Abrupt cessation of reboxetine along alcohol deprivation results in alcohol intake escalation after reinstatement of drinking
Ballesta, A; Alen, F; Orio, L; Arco, R; Vadas, E; Decara, J; Vargas, A; de Heras, RG; Ramirez-Lopez, M; Serrano, A; Pavon, FJ; Suarez, J; de Fonseca, FR ADDICTION BIOLOGY 2021
Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis
Fransson, J; Gomez-Conde, AI; Romero-Imbroda, J; Fernandez, O; Leyva, L; de Fonseca, FR; Chun, J; Louapre, C; Van-Evercooren, AB; Zujovic, V; Estivill-Torrus, G; Garcia-Diaz, B MOLECULAR NEUROBIOLOGY 2021
Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol
Medina-Vera D, Navarro JA, Tovar R, Rosell-Valle C, Gutiérrez-Adan A, et al. Nutrients 2021 Jun 30;13(7):
Adolescent binge-ethanol accelerates cognitive impairment and beta-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice
Ledesma, JC; Rodriguez-Arias, M; Gavito, AL; Sanchez-Perez, AM; Vina, J; Vera, DM; de Fonseca, FR; Minarro, J ADDICTION BIOLOGY 2021
Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming
Tovar R, Vargas A, Aranda J, Sánchez-Salido L, González-González L, et al. International journal of molecular sciences 2021 Jun 11;22(12):
ATP13A2 levels in serum and cerebrospinal fluid in patients with idiopathic Parkinson’s disease
Fernandez-Espejo, E; de Fonseca, FR; Suarez, J; Gonzalez-Aparicio, R; Santurtun, A PARKINSONISM & RELATED DISORDERS 2021
Cerebellar and cortical TLR4 activation and behavioral impairments in Wernicke-Korsakoff Syndrome: Pharmacological effects of oleoylethanolamide
Moya, M; San Felipe, D; Ballesta, A; Alen, F; de Fonseca, FR; Garcia-Bueno, B; Marco, EM; Orio, L PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2021
Cerebrospinal fluid lactoperoxidase level is enhanced in idiopathic Parkinson’s disease, and correlates with levodopa equivalent daily dose
Fernandez-Espejo, E; de Fonseca, FR; Suarez, J; de Pablos, AM BRAIN RESEARCH 2021
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis
Rosell-Valle, C; Pedraza, C; Manuel, I; Moreno-Rodriguez, M; Rodriguez-Puertas, R; Castilla-Ortega, E; Carames, JM; Conde, AIG; Zambrana-Infantes, E; Ortega-Pinazo, J; Serrano-Castro, PJ; Chun, J; De Fonseca, FR; Santin, LJ; Estivill-Torrus, G PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2021
Cocaine and depressive disorders: When standard clinical diagnosis is insufficient
Alias-Ferri, M; Garcia-Marchena, N; Mestre-Pinto, JI; Araos, P; Vergara-Moragues, E; Fonseca, F; Gonzalez-Saiz, F; de Fonseca, FR; Torrens, M; Mateus, J; Papaseit, E; Perez-Mana, C; Rodriguez-Minguela, R; Rossi, P; Tamarit, C; Vallecillo, G ADICCIONES 2021
Energy sensors in drug addiction: A potential therapeutic target
Lopez-Gambero, AJ; de Fonseca, FR; Suarez, J ADDICTION BIOLOGY 2021
Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence
Rico-Barrio I, Peñasco S, Lekunberri L, Serrano M, Egaña-Huguet J, et al. Biomedicines 2021 Jul 16;9(7):
Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
Requena-Ocaña N, Araos P, Flores M, García-Marchena N, Silva-Peña D, et al. Scientific reports 2021 Aug 2;11(1):15583
GABAergic deficits in absence of LPA(1) receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
Rosell-Valle, C; Martinez-Losa, M; Matas-Rico, E; Castilla-Ortega, E; Zambrana-Infantes, E; Gomez-Conde, AI; Sanchez-Salido, L; de Guevara-Miranda, DL; Pedraza, C; Serrano-Castro, PJ; Chun, J; de Fonseca, FR; Alvarez-Dolado, M; Santin, LJ; Estivill-Torrus, G BRAIN STRUCTURE & FUNCTION 2021
Gender Perspective in Dual Diagnosis
Torrens-Melich M, Orengo T, Rodríguez de Fonseca F, Almodóvar I, Baquero A, et al. Brain sciences 2021 Aug 21;11(8):
Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210
Serrano, A; Vadas, E; Ferrer, B; Bilbao, A; Granado, N; Suarez, J; Pavon, FJ; Moratalla, R; de Fonseca, FR PSYCHOPHARMACOLOGY 2021
Immunomodulatory, Antioxidant Activity and Cytotoxic Effect of Sulfated Polysaccharides from Porphyridium cruentum. (S.F.Gray) Nageli
Casas-Arrojo V, Decara J, de Los Ángeles Arrojo-Agudo M, Pérez-Manríquez C, Abdala-Díaz RT Biomolecules 2021 Mar 24;11(4):
Influence of gender and education on cocaine users in an outpatient cohort in Spain
Requena-Ocaña N, Flores-Lopez M, Martín AS, García-Marchena N, Pedraz M, et al. Scientific reports 2021 Oct 22;11(1):20928
Met and Unmet Needs in an Inpatient Psychiatry Setting in Spain
Gomez-Sanchez-Lafuente C, Guzman-Parra J, Lopez-Zambrano MA, Moreno-Kustner B, Mayoral-Cleries F Neuropsychiatric disease and treatment 2021;17():1859-1868
Microglia activated by microbial neuraminidase contributes to ependymal cell death
Fernández-Arjona MDM, León-Rodríguez A, López-Ávalos MD, Grondona JM Fluids and barriers of the CNS 2021 Mar 23;18(1):15
Native alpha-Synuclein, 3-Nitrotyrosine Proteins, and Patterns of Nitro-alpha-Synuclein-Immunoreactive Inclusions in Saliva and Submandibulary Gland in Parkinson’s Disease
Fernández-Espejo E, Rodríguez de Fonseca F, Suárez J, Tolosa E, Vilas D, et al. Antioxidants (Basel, Switzerland) 2021 May 1;10(5):
Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?
de Ceglia M, Decara J, Gaetani S, Rodríguez de Fonseca F Pharmaceuticals (Basel, Switzerland) 2021 Sep 29;14(10):
Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
Tovar R, Gavito AL, Vargas A, Soverchia L, Hernandez-Folgado L, et al. Nutrients 2021 Jul 28;13(8):
Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine
Mañas-Padilla MC, Ávila-Gámiz F, Gil-Rodríguez S, Ladrón de Guevara-Miranda D, Rodríguez de Fonseca F, et al. Physiology & behavior 2021 Oct 15;240():113542
Pigment epithelium-derived factor (PEDF) and PEDF-receptor in the adult mouse brain: Differential spatial/temporal localization pattern
de Diego-Otero, Y; Giraldez-Perez, RM; Lima-Cabello, E; Heredia-Farfan, R; Medina, RC; Sanchez-Salido, L; Costillas, LP JOURNAL OF COMPARATIVE NEUROLOGY 2021
Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder
Galván ST, Flores-López M, Romero-Sanchiz P, Requena-Ocaña N, Porras-Perales O, et al. Scientific reports 2021 Jul 1;11(1):13629
Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease
Flores-López M, García-Marchena N, Pavon FJ, Lara E, Porras-Perales O, et al. Biomedicines 2021 Sep 13;9(9):
Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease
Barrios V, Chowen JA, Martín-Rivada Á, Guerra-Cantera S, Pozo J, et al. Cells 2021 Dec 18;10(12):
Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency
Rubio L, Vargas A, Rivera P, López-Gambero AJ, Tovar R, et al. International journal of molecular sciences 2021 Apr 14;22(8):
Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition
Manas-Padilla, MC; Gil-Rodriguez, S; Sampedro-Piquero, P; Avila-Gamiz, F; de Fonseca, FR; Santin, LJ; Castilla-Ortega, E ADDICTION BIOLOGY 2021
Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex
Pavón FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, et al. Neurobiology of stress 2021 May;14():100293
Sex-specific Associations of Alcohol Withdrawal in Patients Admitted for the Treatment of Alcohol Use Disorder
Sanvisens, A; Zuluaga, P; Short, A; Rubio, G; Gual, A; Torrens, M; Fuster, D; Bolao, F; de Fonseca, FR; Muga, R JOURNAL OF ADDICTION MEDICINE 2021
Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamineD1or dopamineD2receptors
Rivera, P; Aranda, J; Alen, F; Vargas, A; Serrano, A; Pavon, FJ; Orio, L; Rubio, L; Moratalla, R; de Fonseca, FR; Suarez, J JOURNAL OF COMPARATIVE NEUROLOGY 2021
Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain
Aranda J, Fernández-Arjona MDM, Alén F, Rivera P, Rubio L, et al. Brain structure & function 2021 Sep;226(7):2243-2264
The Immune System through the Lens of Alcohol Intake and Gut Microbiota
Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Durán-González P, Morales-García JÁ, et al. International journal of molecular sciences 2021 Jul 13;22(14):
A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA(1)), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration
González-Gil I, Zian D, Vázquez-Villa H, Hernández-Torres G, Martínez RF, et al. Journal of medicinal chemistry 2020 Mar 12;63(5):2372-2390
Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases
García-Marchena N, Maza-Quiroga R, Serrano A, Barrios V, Requena-Ocaña N, et al. Journal of psychopharmacology (Oxford, England) 2020 Nov;34(11):1250-1260
Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments
Castilla-Ortega E, Santín LJ Current opinion in pharmacology 2020 Feb;50():109-116
Better data, better policy and better lives: a call for improved drug monitoring and concerted responses
Comiskey C, Bretteville-Jensen AL, Bergeron H, Bühringer G, Dargan P, et al. Addiction (Abingdon, England) 2020 Feb;115(2):199-200
Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala
Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, et al. Addiction biology 2020 Sep;25(5):e12813
Cocaine-induced changes in CX(3)CL1 and inflammatory signaling pathways in the hippocampus: Association with IL1 beta
Montesinos J, Castilla-Ortega E, Sánchez-Marín L, Montagud-Romero S, Araos P, et al. Neuropharmacology 2020 Jan 1;162():107840
COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats
Pavon FJ, Polis I, Stouffer DG, Roberto M, Martin-Fardon R, et al. Alcoholism, clinical and experimental research 2020 Nov;44(11):2158-2165
D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome
Pericuesta E, Laguna-Barraza R, Ramos-Ibeas P, Gutierrez-Arroyo JL, Navarro JA, et al. International journal of molecular sciences 2020 Aug 22;21(17):
Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in paracetamol-induced liver injury
Rivera P, Vargas A, Pastor A, Boronat A, López-Gambero AJ, et al. British journal of pharmacology 2020 Jul;177(14):3309-3326
D-Pinitol fromCeratonia siliquaIs an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats
Navarro JA, Decara J, Medina-Vera D, Tovar R, Suarez J, et al. Nutrients 2020 Jul 8;12(7):
DSM-5 in patients seeking their first treatment for alcohol use disorder. Sex differences in the multicenter CohRTA study
Sanvisens A, Zuluaga P, Rubio G, Short A, Gual A, et al. Adicciones 2020 Apr 1;32(2):136-144
Epicardial cell lineages and the origin of the coronary endothelium
Carmona R, Barrena S, López Gambero AJ, Rojas A, Muñoz-Chápuli R FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5223-5239
‘I have anxiety, but I have values and preferences’ Experiences of users with generalized anxiety disorder: A qualitative study
Hurtado MM, Villena A, Vega A, Amor G, Gómez C, et al. International journal of mental health nursing 2020 Jun;29(3):521-530
Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity
Medina-Vera D, Rosell-Valle C, López-Gambero AJ, Navarro JA, Zambrana-Infantes EN, et al. Biology 2020 Nov 5;9(11):
Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators />
Sanchez-Marin L, Gavito AL, Decara J, Pastor A, Castilla-Ortega E, et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2020 Apr;33():126-138
Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?
Serrano-Castro PJ, Estivill-Torrús G, Cabezudo-García P, Reyes-Bueno JA, Ciano Petersen N, et al. Neurologia (Barcelona, Spain) 2020 May;35(4):245-251
Inhibition of Receptor Protein Tyrosine Phosphatase beta/zeta Reduces Alcohol Intake in Rats
Calleja-Conde J, Fernández-Calle R, Zapico JM, Ramos A, de Pascual-Teresa B, et al. Alcoholism, clinical and experimental research 2020 May;44(5):1037-1045
Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice
Peñasco S, Rico-Barrio I, Puente N, Fontaine CJ, Ramos A, et al. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Jan;45(2):309-318
LPA(1) receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance
Moreno-Fernández RD, Rosell-Valle C, Bacq A, Zanoletti O, Cifuentes M, et al. Neuropharmacology 2020 Mar 1;164():107896
Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division
Valcárcel-Martín R, Martín-Suárez S, Muro-García T, Pastor-Alonso O, Rodríguez de Fonseca F, et al. Frontiers in neuroscience 2020;14():811
Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases
Decara J, Rivera P, López-Gambero AJ, Serrano A, Pavón FJ, et al. Frontiers in pharmacology 2020;11():730
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity
Vidal R, García-Marchena N, O’Shea E, Requena-Ocaña N, Flores-López M, et al. Progress in neuro-psychopharmacology & biological psychiatry 2020 Aug 30;102():109958
Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients
García-Marchena N, Pizarro N, Pavón FJ, Martínez-Huélamo M, Flores-López M, et al. Scientific reports 2020 Oct 13;10(1):17163
Sex-Specific Anxiety and Prefrontal Cortex Glutamatergic Dysregulation Are Long-Term Consequences of Pre-and Postnatal Exposure to Hypercaloric Diet in a Rat Model
Rivera P, Tovar R, Ramírez-López MT, Navarro JA, Vargas A, et al. Nutrients 2020 Jun 19;12(6):
Social defeat-induced increase in the conditioned rewarding effects of cocaine: Role of CX3CL1
Montagud-Romero S, Montesinos J, Pavón FJ, Blanco-Gandia MC, Ballestín R, et al. Progress in neuro-psychopharmacology & biological psychiatry 2020 Jan 10;96():109753
Spectrophotometric Color Measurement to Assess Temperature of Exposure in Cortical and Medullar Heated Human Bones: A Preliminary Study
Rubio L, Díaz-Vico R, Smith-Fernández I, Smith-Fernández A, Suárez J, et al. Diagnostics (Basel, Switzerland) 2020 Nov 20;10(11):
The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases
López-Gambero AJ, Sanjuan C, Serrano-Castro PJ, Suárez J, Rodríguez de Fonseca F Biomedicines 2020 Aug 20;8(9):
The influence of dopaminergic polymorphisms on selective stopping
Rincón-Pérez I, Echeverry-Alzate V, Sánchez-Carmona AJ, Bühler KM, Hinojosa JA, et al. Behavioural brain research 2020 Mar 2;381():112441
Variation in chemokines plasma concentrations in primary care depressed patients associated with Internet-based cognitive-behavioral therapy
Romero-Sanchiz P, Nogueira-Arjona R, Araos P, Serrano A, Barrios V, et al. Scientific reports 2020 Jan 23;10(1):1078
A novel approach to childhood obesity: circulating chemokines and growth factors as biomarkers of insulin resistance
Rivera P, Martos-Moreno GÁ, Barrios V, Suárez J, Pavón FJ, et al. Pediatric obesity 2019 Mar;14(3):e12473
Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis
Suárez J, Rivera P, Aparisi Rey A, Pérez-Martín M, Arrabal S, et al. Psychoneuroendocrinology 2019 Dec;110():104418
Adult-onset hypothyroidism increases ethanol consumption
Echeverry-Alzate V, Bühler KM, Calleja-Conde J, Huertas E, Maldonado R, et al. Psychopharmacology 2019 Apr;236(4):1187-1197
Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats
Silva-Peña D, García-Marchena N, Alén F, Araos P, Rivera P, et al. Addiction biology 2019 Sep;24(5):1019-1033
Brain Glucose-Sensing Mechanism and Energy Homeostasis
López-Gambero AJ, Martínez F, Salazar K, Cifuentes M, Nualart F Molecular neurobiology 2019 Feb;56(2):769-796
Bupropion, a possible antidepressant without negative effects on alcohol relapse
Ballesta A, Orio L, Arco R, Vargas A, Romero-Sanchiz P, et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2019 Jun;29(6):756-765
CB1 and LPA(1) Receptors Relationship in the Mouse Central Nervous System
González de San Román E, Manuel I, Ledent C, Chun J, Rodríguez de Fonseca F, et al. Frontiers in molecular neuroscience 2019;12():223
Cell Phone Use Habits Among the Spanish Population: Contribution of Applications to Problematic Use
De-Sola J, Rubio G, Talledo H, Pistoni L, Van Riesen H, et al. Frontiers in psychiatry 2019;10():883
Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats
Millón C, Flores-Burgess A, Castilla-Ortega E, Gago B, García-Fernandez M, et al. Addiction biology 2019 Jan;24(1):76-87
Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence
Rico-Barrio I, Peñasco S, Puente N, Ramos A, Fontaine CJ, et al. Addiction biology 2019 Sep;24(5):969-980
Defensive pessimism, optimism and adaptation to chronic pain
Flores-Lopez, M; Serrano-Ibanez, ER; Ramirez-Maestre, C; Lopez-Martinez, AE; Ruiz-Parraga, GT; Esteve, R BEHAVIORAL PSYCHOLOGY-PSICOLOGIA CONDUCTUAL 2019
Effects of the LPA(1) Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice
Tabbai S, Moreno-Fernández RD, Zambrana-Infantes E, Nieto-Quero A, Chun J, et al. Frontiers in molecular neuroscience 2019;12():146
Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice
Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, et al. Addiction biology 2019 Nov;24(6):1204-1215
Highlighting the Role of Cognitive and Brain Reserve in the Substance use Disorder Field
Cutuli D, Ladrón de Guevara-Miranda D, Castilla-Ortega E, Santín LJ, Sampedro-Piquero P Current neuropharmacology 2019;17(11):1056-1070
Inflammatory mediators and dual depression: Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders
García-Marchena N, Barrera M, Mestre-Pintó JI, Araos P, Serrano A, et al. PloS one 2019;14(3):e0213791
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
Ladrón de Guevara-Miranda D, Moreno-Fernández RD, Gil-Rodríguez S, Rosell-Valle C, Estivill-Torrús G, et al. Addiction biology 2019 May;24(3):458-470
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro-Piquero P, Ladrón de Guevara-Miranda D, Pavón FJ, Serrano A, Suárez J, et al. Neuroscience and biobehavioral reviews 2019 Nov;106():23-48
Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Delta(9)-THC and Ethanol Binge Drinking During Adolescence
Silva-Peña D, Rivera P, Alén F, Vargas A, Rubio L, et al. Frontiers in molecular neuroscience 2019;12():96
Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum
Rivera P, Silva-Peña D, Blanco E, Vargas A, Arrabal S, et al. Neuropharmacology 2019 Mar 1;146():184-197
Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse
Orio L, Alen F, Pavón FJ, Serrano A, García-Bueno B Frontiers in molecular neuroscience 2018;11():490
Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood
Rivera P, Ramírez-López MT, Vargas A, Decara J, Vázquez M, et al. Acta physiologica (Oxford, England) 2019 Jun;226(2):e13244
Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants
Romero-Sanchiz P, Nogueira-Arjona R, Pastor A, Araos P, Serrano A, et al. Neuropharmacology 2019 May 1;149():212-220
Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients
Araos P, Vidal R, O’Shea E, Pedraz M, García-Marchena N, et al. Scientific reports 2019 Nov 14;9(1):16842
Sex-Dimorphic Behavioral Alterations and Altered Neurogenesis in U12 Intron Splicing-Defective Zrsr1 Mutant Mice
Alén F, Gómez-Redondo I, Rivera P, Suárez J, Ramos-Ibeas P, et al. International journal of molecular sciences 2019 Jul 19;20(14):
The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm
Sampedro-Piquero P, Ávila-Gámiz F, Moreno Fernández RD, Castilla-Ortega E, Santín LJ Journal of psychopharmacology (Oxford, England) 2019 Dec;33(12):1501-1511
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Sampedro-Piquero P, Mañas-Padilla MC, Ávila-Gámiz F, Gil-Rodríguez S, Santín LJ, et al. Animal cognition 2019 May;22(3):433-443
Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study
Moreno M, Decara J, Pavon FJ, Stouffer DG, Edwards S, et al. Addiction biology 2018 Nov;23(6):1251-1261
Cooperative role of the glucagon-like peptide-1 receptor and 3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats
Decara J, Rivera P, Arrabal S, Vargas A, Serrano A, et al. Acta physiologica (Oxford, England) 2018 Apr;222(4):e13008
Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake
Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, et al. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2018 Aug;43(9):1840-1850
Effects of genetic deletion versus pharmacological blockade of the LPA(1) receptor on depression-like behaviour and related brain functional activity
Moreno-Fernández RD, Nieto-Quero A, Gómez-Salas FJ, Chun J, Estivill-Torrús G, et al. Disease models & mechanisms 2018 Sep 10;11(9):
Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens
Pavon FJ, Serrano A, Sidhpura N, Polis I, Stouffer D, et al. Addiction biology 2018 Mar;23(2):723-734
Higher Impulsivity As a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders
García-Marchena N, Ladrón de Guevara-Miranda D, Pedraz M, Araos PF, Rubio G, et al. Frontiers in psychiatry 2018;9():26
Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice
Horiuchi K, Perez-Cerezales S, Papasaikas P, Ramos-Ibeas P, López-Cardona AP, et al. Cell reports 2018 Apr 3;23(1):143-155
Inclusion of Alcoholic Associations Into a Public Treatment Programme for Alcoholism Improves Outcomes During the Treatment and Continuing Care Period: A 6-Year Experience
Rubio G, Marín M, Arias F, López-Trabada JR, Iribarren M, et al. Alcohol and alcoholism (Oxford, Oxfordshire) 2018 Jan 1;53(1):78-88
Increased plasma oleoylethanolamide and palmitoleoylethanolamide levels correlate with inflammatory changes in alcohol binge drinkers: the case of HMGB1 in women
Antón M, Rodríguez-González A, Rodríguez-Rojo IC, Pastor A, Correas Á, et al. Addiction biology 2018 Nov;23(6):1242-1250
Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects
Coín-Aragüez L, Pavón FJ, Contreras A, Gentile AM, Lhamyani S, et al. Scientific reports 2018 Nov 30;8(1):17518
Octadecylpropyl Sulfamide Reduces Neurodegeneration and Restores the Memory Deficits Induced by Hypoxia-Ischemia in Mice
Kossatz E, Silva-Peña D, Suárez J, de Fonseca FR, Maldonado R, et al. Frontiers in pharmacology 2018;9():376
Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice
Zambrana-Infantes E, Rosell Del Valle C, Ladrón de Guevara-Miranda D, Galeano P, Castilla-Ortega E, et al. Pharmacology, biochemistry, and behavior 2018 Mar;166():1-12
Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia
Holubiec MI, Romero JI, Suárez J, Portavella M, Fernández-Espejo E, et al. Psychopharmacology 2018 Oct;235(10):2929-2945
Patients with alcohol use disorder: initial results from a prospective multicenter registry in the Spanish Network on Addiction Disorders. CohRTA Study
Sanvisens A, Zuluaga P, Rivas I, Rubio G, Gual A, et al. Adicciones 2018 Jan 12;30(4):292-300
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure
Rivera P, Fernández-Arjona MDM, Silva-Peña D, Blanco E, Vargas A, et al. Biochemical pharmacology 2018 Nov;157():244-257
PPAR alpha/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models
Alen F, Decara J, Brunori G, You ZB, Bühler KM, et al. Biochemical pharmacology 2018 Nov;157():235-243
Red Bull (R) energy drink increases consumption of higher concentrations of alcohol
Roldán M, Echeverry-Alzate V, Bühler KM, Sánchez-Diez IJ, Calleja-Conde J, et al. Addiction biology 2018 Sep;23(5):1094-1105
Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA(1) Pathway
Moreno-Fernandez RD, Tabbai S, Castilla-Ortega E, Perez-Martin M, Estivill-Torrus G, et al. Current neuropharmacology 2018 Mar 5;16(3):271-283
Systemic blockade of LPA(1/3) lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior
Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, et al. Neuropharmacology 2018 May 1;133():189-201
The adiponectin promoter activator NP-1 induces high levels of circulating TNF alpha and weight loss in obese (fa/fa) Zucker rats
Decara J, Serrano A, Pavón FJ, Rivera P, Arco R, et al. Scientific reports 2018 Jun 29;8(1):9858
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
Sampedro-Piquero P, Moreno-Fernández RD, Mañas-Padilla MC, Gil-Rodríguez S, Gavito AL, et al. Neurobiology of learning and memory 2018 May;151():35-42
A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner
Ramírez-López MT, Vázquez M, Lomazzo E, Hofmann C, Blanco RN, et al. PloS one 2017;12(3):e0174307
A Positive Allosteric Modulator of the Serotonin 5-HT2c Receptor for Obesity
García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, et al. Journal of medicinal chemistry 2017 Dec 14;60(23):9575-9584
Acetaminophen-Induced Liver Injury Alters the Acyl Ethanolamine-Based Anti-Inflammatory Signaling System in Liver
Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, et al. Frontiers in pharmacology 2017;8():705
Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
Holubiec MI, Romero JI, Blanco E, Tornatore TL, Suarez J, et al. Neuroscience letters 2017 Jul 13;653():269-275
Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders
García-Marchena N, Silva-Peña D, Martín-Velasco AI, Villanúa MÁ, Araos P, et al. PloS one 2017;12(11):e0187634
Development of a Mobile Phone addiction craving scale and its Validation in a spanish adult Population
De-Sola J, Talledo H, Rubio G, de Fonseca FR Frontiers in psychiatry 2017;8():90
Differences in the Rates of Drug Polyconsumption and Psychiatric Comorbidity among Patients with Cocaine Use Disorders According to the Mental Health Service
Araos P, Vergara-Moragues E, González-Saiz F, Pedraz M, García-Marchena N, et al. Journal of psychoactive drugs 2017 Sep-Oct;49(4):306-315
Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction
Rivera A, Gago B, Suárez-Boomgaard D, Yoshitake T, Roales-Buján R, et al. Addiction biology 2017 Sep;22(5):1232-1245
Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation
Sanchez-Marin L, Pavon FJ, Decara J, Suarez J, Gavito A, et al. Frontiers in behavioral neuroscience 2017;11():15
Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGF alpha) as a potential biomarker of consumption and dual diagnosis
Maza-Quiroga R, García-Marchena N, Romero-Sanchiz P, Barrios V, Pedraz M, et al. PeerJ 2017;5():e3926
Glutamate and Brain Glutaminases in Drug Addiction
Márquez J, Campos-Sandoval JA, Peñalver A, Matés JM, Segura JA, et al. Neurochemical research 2017 Mar;42(3):846-857
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver A, Campos-Sandoval JA, Blanco E, Cardona C, Castilla L, et al. Frontiers in molecular neuroscience 2017;10():278
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis
Ladrón de Guevara-Miranda D, Millón C, Rosell-Valle C, Pérez-Fernández M, Missiroli M, et al. Disease models & mechanisms 2017 Mar 1;10(3):323-336
Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats
Marco EM, Peñasco S, Hernández MD, Gil A, Borcel E, et al. Frontiers in behavioral neuroscience 2017;11():233
maLPA1-null mice as an endophenotype of anxious depression
Moreno-Fernández RD, Pérez-Martín M, Castilla-Ortega E, Rosell Del Valle C, García-Fernández MI, et al. Translational psychiatry 2017 Apr 4;7(4):e1077
Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration
Romero JI, Holubiec MI, Tornatore TL, Rivière S, Hanschmann EM, et al. Oxidative medicine and cellular longevity 2017;2017():4162465
Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration
Antón M, Alén F, Gómez de Heras R, Serrano A, Pavón FJ, et al. Addiction biology 2017 May;22(3):724-741
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity
García-Marchena N, Araos PF, Barrios V, Sánchez-Marín L, Chowen JA, et al. Frontiers in psychiatry 2016;7():214
Plasma concentrations of oleoylethanolamide and other acylethanolamides are altered in alcohol-dependent patients: effect of length of abstinence
Garcia-Marchena N, Pavon FJ, Pastor A, Araos P, Pedraz M, et al. Addiction biology 2017 Sep;22(5):1366-1377
Prevalence of problematic cell phone use in an adult population in Spain as assessed by the Mobile Phone Problem Use Scale (MPPUS)
de-Sola J, Talledo H, Rodríguez de Fonseca F, Rubio G PloS one 2017;12(8):e0181184
Psychiatric comorbidity and plasma levels of 2-acyl-glycerols in outpatient treatment alcohol users. Analysis of gender differences
García Marchena N, Araos P, Pavón FJ, Ponce G, Pedraz M, et al. Adicciones 2016 Sep 29;29(2):83-96
Psychological Factors and Alcohol Use in Problematic Mobile Phone Use in the Spanish Population
De-Sola J, Talledo H, Rubio G, de Fonseca FR Frontiers in psychiatry 2017;8():11
Text mining and expert curation to develop a database on psychiatric diseases and their genes
Gutiérrez-Sacristán A, Bravo À, Portero-Tresserra M, Valverde O, Armario A, et al. Database : the journal of biological databases and curation 2017 Jan 1;2017():
The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice
Giné E, Echeverry-Alzate V, Lopez-Moreno JA, Rodriguez de Fonseca F, Perez-Castillo A, et al. Neuropharmacology 2017 Apr;116():132-141
The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder
Castilla-Ortega E, Ladrón de Guevara-Miranda D, Serrano A, Pavón FJ, Suárez J, et al. Biochemical pharmacology 2017 Oct 1;141():100-117
The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours
Millón C, Flores-Burgess A, Narváez M, Borroto-Escuela DO, Gago B, et al. Neuropeptides 2017 Aug;64():39-45
A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis
Castilla-Ortega E, Serrano A, Blanco E, Araos P, Suárez J, et al. Neuroscience and biobehavioral reviews 2016 Jul;66():15-32
An Internet-Based Intervention for Depression in Primary Care in Spain: A Randomized Controlled Trial
Montero-Marín J, Araya R, Pérez-Yus MC, Mayoral F, Gili M, et al. Journal of medical Internet research 2016 Aug 26;18(8):e231
Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators
Decara J, Arrabal S, Beiroa D, Rivera P, Vargas A, et al. BioFactors (Oxford, England) 2016 Nov 12;42(6):600-611
Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA(1) receptor results in increased alcohol consumption
Castilla-Ortega E, Pavón FJ, Sánchez-Marín L, Estivill-Torrús G, Pedraza C, et al. Neuropharmacology 2016 Apr;103():92-103
Can symptoms help in differential diagnosis between substance-induced vs independent psychosis in adults with a lifetime diagnosis of cocaine use disorder?
Vergara-Moragues E, Mestre-Pintó JI, Gómez PA, Rodríguez-Fonseca F, Torrens M, et al. Psychiatry research 2016 Aug 30;242():94-100
Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration
Mendizabal-Zubiaga J, Melser S, Bénard G, Ramos A, Reguero L, et al. Frontiers in physiology 2016;7():476
Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice
Gavito AL, Bautista D, Suarez J, Badran S, Arco R, et al. PloS one 2016;11(6):e0157956
Cocaine-conditioned place preference is predicted by previous anxiety-like behavior and is related to an increased number of neurons in the basolateral amygdala
Ladrón de Guevara-Miranda D, Pavón FJ, Serrano A, Rivera P, Estivill-Torrús G, et al. Behavioural brain research 2016 Feb 1;298(Pt B):35-43
Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus
Blanco E, Galeano P, Palomino A, Pavón FJ, Rivera P, et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2016 Mar;26(3):477-92
Effects of Adolescent Intermittent Alcohol Exposure on the Expression of Endocannabinoid Signaling-Related Proteins in the Spleen of Young Adult Rats
Pavón FJ, Marco EM, Vázquez M, Sánchez L, Rivera P, et al. PloS one 2016;11(9):e0163752
ENVIRONMENTAL ENRICHMENT AS A THERAPEUTIC AVENUE FOR ANXIETY IN AGED WISTAR RATS: EFFECT ON CAT ODOR EXPOSITION AND GABAergic INTERNEURONS
Sampedro-Piquero P, Castilla-Ortega E, Zancada-Menendez C, Santín LJ, Begega A Neuroscience 2016 Aug 25;330():17-25
Environmental Enrichment, Age, and PPAR alpha Interact to Regulate Proliferation in Neurogenic Niches
Pérez-Martín M, Rivera P, Blanco E, Lorefice C, Decara J, et al. Frontiers in neuroscience 2016;10():89
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring
Ramírez-López MT, Vázquez M, Bindila L, Lomazzo E, Hofmann C, et al. Frontiers in behavioral neuroscience 2015;9():339
Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring
Ramírez-López MT, Arco R, Decara J, Vázquez M, Noemí Blanco R, et al. PloS one 2016;11(11):e0165432
Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators
Ramírez-López MT, Arco R, Decara J, Vázquez M, Rivera P, et al. Frontiers in behavioral neuroscience 2016;10():241
Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
Ramírez-López MT, Vázquez M, Bindila L, Lomazzo E, Hofmann C, et al. Frontiers in behavioral neuroscience 2016;10():208
Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood
Calleja-Conde J, Echeverry-Alzate V, Giné E, Bühler KM, Nadal R, et al. British journal of pharmacology 2016 Aug;173(16):2490-505
Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm
Castilla-Ortega E, Blanco E, Serrano A, Ladrón de Guevara-Miranda D, Pedraz M, et al. Addiction biology 2016 May;21(3):575-88
Role of the satiety factor oleoylethanolamide in alcoholism
Bilbao A, Serrano A, Cippitelli A, Pavón FJ, Giuffrida A, et al. Addiction biology 2016 Jul;21(4):859-72
Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice
Gavito AL, Cabello R, Suarez J, Serrano A, Pavón FJ, et al. British journal of pharmacology 2016 Mar;173(6):1070-84
Spinal cord compression injury in lysophosphatidic acid 1 receptor-null mice promotes maladaptive pronociceptive descending control.
Suardíaz M, Galan-Arriero I, Avila-Martin G, Estivill-Torrús G, de Fonseca FR, et al. European journal of pain (London, England) 2016 Feb;20(2):176-85
Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury
Santos-Nogueira E, López-Serrano C, Hernández J, Lago N, Astudillo AM, et al. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jul 15;35(28):10224-35
Anatomical location of LPA(1) activation and LPA phospholipid precursors in rodent and human brain
González de San Román E, Manuel I, Giralt MT, Chun J, Estivill-Torrús G, et al. Journal of neurochemistry 2015 Aug;134(3):471-85
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice
Vida M, Gavito AL, Pavón FJ, Bautista D, Serrano A, et al. Disease models & mechanisms 2015 Jul 1;8(7):721-31
Cocaine-Induced Behavioral Sensitization Is Associated With Changes in the Expression of Endocannabinoid and Glutamatergic Signaling Systems in the Mouse Prefrontal Cortex
Blanco E, Pavón FJ, Palomino A, Luque-Rojas MJ, Serrano A, et al. The international journal of neuropsychopharmacology 2014 Oct 31;18(1):
Common single nucleotide variants underlying drug addiction: more than a decade of research
Bühler KM, Giné E, Echeverry-Alzate V, Calleja-Conde J, de Fonseca FR, et al. Addiction biology 2015 Sep;20(5):845-71
Effects of Synchronous and Asynchronous Embryo Transfer on Postnatal Development, Adult Health, and Behavior in Mice
López-Cardona AP, Fernández-González R, Pérez-Crespo M, Alén F, de Fonseca FR, et al. Biology of reproduction 2015 Oct;93(4):85
Expectations Among Patients and Health Professionals Regarding Web-Based Interventions for Depression in Primary Care: A Qualitative Study
Montero-Marín J, Prado-Abril J, Botella C, Mayoral-Cleries F, Baños R, et al. Journal of medical Internet research 2015 Mar 10;17(3):e67
Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans
López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, et al. Alcoholism, clinical and experimental research 2015 Oct;39(10):1939-50
Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia
Galeano P, Blanco E, Logica Tornatore TM, Romero JI, Holubiec MI, et al. Frontiers in behavioral neuroscience 2014;8():406
Loss of lysophosphatidic acid receptor LPA(1) alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex
García-Díaz B, Riquelme R, Varela-Nieto I, Jiménez AJ, de Diego I, et al. Brain structure & function 2015 Nov;220(6):3701-20
Narrow Specificity of Responsibility and Intolerance of Uncertainty in Obsessive-Compulsive Behavior and Generalized Anxiety Symptoms
Romero-Sanchiz, P; Nogueira-Arjona, R; Godoy-Avila, A; Gavino-Lazaro, A; Freeston, MH INTERNATIONAL JOURNAL OF COGNITIVE THERAPY 2015
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation
Fresno N, Macías-González M, Torres-Zaguirre A, Romero-Cuevas M, Sanz-Camacho P, et al. Journal of medicinal chemistry 2015 Aug 27;58(16):6639-52
Perinatal asphyxia results in altered expression of the hippocampal acylethanolamide/endocannabinoid signaling system associated to memory impairments in postweaned rats
Blanco E, Galeano P, Holubiec MI, Romero JI, Logica T, et al. Frontiers in neuroanatomy 2015;9():141
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain
Rivera P, Blanco E, Bindila L, Alen F, Vargas A, et al. Frontiers in cellular neuroscience 2015;9():379
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
Arrabal S, Lucena MA, Canduela MJ, Ramos-Uriarte A, Rivera P, et al. PloS one 2015;10(12):e0145244
Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context
Rivera P, Bindila L, Pastor A, Pérez-Martín M, Pavón FJ, et al. Frontiers in cellular neuroscience 2015;9():98
Plasma Concentrations of BDNF and IGF-1 in Abstinent Cocaine Users with High Prevalence of Substance Use Disorders: Relationship to Psychiatric Comorbidity
Pedraz M, Martín-Velasco AI, García-Marchena N, Araos P, Serrano A, et al. PloS one 2015;10(3):e0118610
Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity
Araos P, Pedraz M, Serrano A, Lucena M, Barrios V, et al. Addiction biology 2015 Jul;20(4):756-72
Spectrophotometric analysis of color changes in teeth incinerated at increasing temperatures
Rubio L, Sioli JM, Suarez J, Gaitan MJ, Martin-de-las-Heras S Forensic science international 2015 Jul;252():193.e1-6
Systemic Administration of Oleoylethanolamide Protects from Neuroinflammation and Anhedonia Induced by LPS in Rats
Sayd A, Antón M, Alén F, Caso JR, Pavón J, et al. The international journal of neuropsychopharmacology 2014 Dec 28;18(6):
THE ROLE OF MATERNAL DIET IN METABOLIC AND BEHAVIOURAL PROGRAMMING: REVIEW OF BIOLOGIC MECHANISMS INVOLVED
Ramírez-López MT, Vázquez Berrios M, Arco González R, Blanco Velilla RN, Decara Del Olmo J, et al. Nutricion hospitalaria 2015 Dec 1;32(6):2433-45
Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats
Decara JM, Pavón FJ, Suárez J, Romero-Cuevas M, Baixeras E, et al. Disease models & mechanisms 2015 Oct 1;8(10):1213-25
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